Installed Windows 10 E 64-bit build 10074, followed by Python 2.7.9 32-bit. Running pip fails the with message Fatal error in launcher: Job information querying failed Issue is open in Github, see below https://github.com/pypa/pip/issues/2748 This issue is also reported in Python.org, see https://bugs.python.org/issue24127 Workaround: C:\>python -m pip install comtypes
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